Murray's 12-game winning streak to start the season came to an end Monday on the road against Wayne of Corydon.
The Class 1A 12th-ranked Falcons defeated the Class 1A 10th-ranked Lady Mustangs 10-0 in six innings.
"We were in the game as the score was 4-0 after five innings," Murray head coach Danny Jensen said. "We really fell apart in the sixth as they exploded for six runs."
Senior Kate Patton issued three walks and gave up three hits, including a three-run home run in the inning. Wayne counterpart, and Southwestern Community College recruit, Breanna Fortune threw a no-hitter against the Lady Mustangs.
Prior to the matchup against Wayne, the Lady Mustangs won the Central Decatur Tournament on Saturday with three wins.
Murray defeated Bedford 7-1, before picking up a 12-0 win over Lamoni in three innings and finishing off the tournament with a 6-4 win over host Central Decatur.
Patton struck out nine Bedford batters in the opening game, while Chellsea Jones and McKenzie McIntosh each had two runs batted in.
Maddy Martin drove in two runs in the win over Lamoni.
Patton worked out of a bases-loaded jam with one out in the sixth inning of the win over Central Decatur. Deena Snyder had three hits with two RBI, while McKenzie Case recorded three hits with one RBI.
Patton, Case, Snyder and Jones were named to the all-tournament team.
Murray played Lamoni in a Bluegrass Conference game Friday before the meeting in Saturday's tournament.
Snyder and Jones each drove in three runs for the Lady Mustangs in the 11-1 win. Snyder recorded two doubles and Jones hit a double and a home run. Patton hit a triple, while striking out nine in the pitching circle.